Dexon Injection is a synthetic long-acting glucocorticoid that depresses formation, release and activity of endogenous mediators of inflammation including prostaglandins, kinins, histamine, liposomal enzymes and complement system. Also modifies body's immune response.

Dexon Injections are used for the treatment of various inflammatory and autoimmune diseases e.g.: 1.Rheumatis; as pain, stiffness or limitation of motion, especially in the joints and related structures, including muscles, bursae, tendons, fibrous tissue.Collagen disease, as lupus erythematosus, dermatomyositis, sclerodema, polyarteritis nodosa, thrombotic purpura. rheumatic fever and rheumatoid arthritis: 2. Allergies, as status asthmaticus, bronchial asthma, contact dermatitis, inflammatory processes of the eye and its adnexa, severe hypersensitivity reactions to drugs or insect stings, anaphylactic shock, impending allograft rejection. 3.Acute adrenocortical insufficiency, as in surgery, severe stress or trauma. Besides Dexon is used as an adjunct in the control of cerebral oedema, as anti-emetic in antineoplastic regimens and for palliative treatment in terminal stages of neoplastic disease.

The dosage of Dexon injection depends on the severity of the condition and the response of the patient. Undesirable effects may be minimized by lowering the dose or adhering to an alternate day dosage regimen. 1. Acute condition, such as shock, severe allergic reactions, fulminating infections, hepatic coma and cerebral oedema, 8 – 40 mg by slow i.v. injection or infusion. Intra-articular 2 - 4mg. 2. Child - (above acute conditions), 0.25 - 0.5 mg/kg body-wt. daily by slow i.v. injection or infusion. 3.Systemic: IV/IM 0.5 to 9 mg/day. 4.Cerebral Edema: IV 10 mg, then IM 4 mg 6 hr until max response. Brain Tumors: IV/IM 2 mg bid to tid. 4.Unresponsive shock: IV 1 to 6 mg/kg as single injection: or 40 mg followed by repeated IV injections 2 to 6 hr. 5.Bacterial meningitis: IV 0.15 mg/kg 6 hr.

Systemic infection, or local infection in or near a joint to be treated, unitesm specific anti-infectve therapy is employed. Hypersensitivity to any ingredient.

History of gastrointestinal lesions; impaired renal function; asthma; pregnancy & lactation; concurrent administration of plasma protein-bound drugs, lithium, beta-blockers or frusemide.

Hypertension; euphoria; psychosis; impaired wound healing; thin fragile skin; hirsutism; acneiform eruptions; increased intra-occular pressure; posterior subcapsular cataract formation;. ulcerative esophagitis; increased appetite and weight gain; hypocaicemia; myopathy, hyperglycemia, insomnia and cushing-like syndrome.

Pregnancy category C. There are no adequate and well controlled studies in pregnant women. Corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Glucocorticoids appear in breast milk. Mothers taking high dosages of corticosteroids should be advised not to breast-feed.

Potential hazardous interactions with lithium, digoxin, diuretics, methotrexate. Aminoglutethimide: May decrease' dexamethasone-induced adrenal suppression.Anticholinesterases: May antagonize antichoiinesterase effects in myasthenia gravis.Anticoagulants, oral: May alter anticoagulant dose requirements.Barbiturates: May decrease effects of dexamethasone.Hydantoins: May increase clearance and decrease therapeutic efficacy of dexamethasone.Rifampicin: May increase clearance and decrease therapeutic efficacy of dexamethasone.Salicylates: May reduce serum levels and efficacy of salicylates. Troleandomycin: May increase dexamethasone effects.Lab Test Interferences: May cause increased urine glucose and serum cholesterol; decreased serum levels of potassium, T3 and T4; decreased uptake of thyroid 131; false-negative nitroblue-tetrazolium test; altered brain scan results; suppression of skin test reactions.

Signs & Symptoms: nausea, skin desquamation, hypertension, dizziness, central obesity, hirsutism, acne.hypertension. osteoporosis, myopathy, sexual dysfunction, diabetes, peptic ulcer.electrolyte and fluid imbalance (chronic cushingoid changes).

Keep in a cool and dry place protected from light.

Dexon Injection: 5's x 2 blistered 1 ml, ampoules in a printed carton.