Cefdiren is a third generation broad spectrum cephalosporin antibiotic for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many beta-lactamases. It kills bacteria by interfering with the synthesis of the bacterial cell wall.

Acute Bacterial Exacerbations of Chronic Bronchitis, Community-Acquired Pneumonia (CAP), Pharyngitis/Tonsillitis, Uncomplicated Skin and Skin-Structure Infections.

Type of Infection Dosage Duration (Days) Community-Acquired Pneumonia 400 mg BID 14 Acute Bacterial Exacerbation of Chronic Bronchitis 400 mg BID 10 Pharyngitis/Tonsillitis 200 mg BID Uncomplicated Skin and Skin Structure Infections Should be taken with meals Use in Renal impaired patient: No dose adjustment is necessary for patients with mild renal impairment (CLcr: 50-80 mL/min/1.73 m2). It is recommended that not more than 200 mg BID be administered to patients with moderate renal impairment (CLcr: 30-49 mL/min/1.73 m2) and 200 mg QD be administered to patients with severe renal impairment (CLcr: < 30 mL/min/1.73 m2). The appropriate dose in patients with end-stage renal disease has not been determined. Use in Hepatically impaired patient: No dose adjustments are necessary for patients with mild or moderate hepatic impairment. The pharmacokinetics of Cefditorenhave not been studied in patients with severe hepatic impairment.

Cefditoren is contraindicated in patients with known allergy to the cephalosporin class of antibiotics or any of its ingredients.

Cefditoren should be prescribed with caution in individuals with a history of gastrointestinal colitis.

Most common side effects are mild and self-limiting include diarrhea, nausea, vaginal moniliasis and headache.

Pregnancy:Cefditorenpivoxil has been assigned to pregnancy category B by the FDA. Lactation: There are no data on the excretion of Cefditorenpivoxil into human milk. Cefditoren is excreted into the milk of rats. So caution is recommended when Cefditorenpivoxil is given to nursing women.

Co-administration of a single dose of an antacid and H2 receptor antagonists may reduce the oral absorption of Cefditorenpivoxil. As with other beta-lactam antibiotics, co-administration of probenecid with cefditorenpivoxil resulted in an increase in the plasma exposure of Cefditoren

Information on Cefditoren overdosage in humans is not available. However, with other ß-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. Hemodialysis may aid in the removal of Cefditoren from the body, particularly if renal function is compromised.

Store in a cool (20º- 25º C) and dry place, keep it away from light and moisture.

Cefdiren 200 Tablet: Each box contains 8 tablets in Alu-Alu blister pack. Cefdiren 400 Tablet: Each box contains 8 tablets in Alu-Alu blister pack.