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Nortriptyline is a tricyclic antidepressant. The mechanism of action of tricyclic antidepressants are at present unknown. Nortriptyline is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine and acetylcholine. It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine. Studies suggest that Nortriptyline interferes with the transport, release and storage of catecholamines.