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Cetirizine Dihydrochloride BP
|5 mg/5 ml
Nosemin (Cetirizine) is a piperazine derivative and a potent antagonist of histamine H1 receptor without any significant anticholinergic and antiserotonin e ffects. It is a long acting antihistamine. Cetirizi ne is rapidly absorbed within 1 hour of oral administrati on. Food does not reduce the extent of its absorpti on. The plasma protein binding is 93%. The terminal eli mination half life ranges from 6.7 hr. to 10.9 hr. The drug is eliminated mainly by renal excretion as unc hanged drug.
Nosemin Tablet: Each film coated tablet contains Cetirizine Dihydrochloride BP 10 mg. Nosemin Syrup: Each 5 ml of syrup contains Cetirizine Dihydrochloride BP 5 mg.
Indications And Uses
Nosemin is indicated for the prevention and symptomatic relief of allergic manifestations such as: • Seasonal allergic rhinitis • Perennial allergic rhinitis • Chronic idiopathic urticaria
Dosage And Administration
Nosemin Tablet: Adults and Children over 6 years: 10 mg (1 tablet) once daily. Nosemin Syrup: Adults and Children over 6 years: 10 mg (2 tea spoonful) d aily. Children (2-6 years): 5 mg (1 teaspoonful) da ily or 2-5 mg (1/2 teaspoonful) twice daily. Dosage in renal & hepatic impairment: Dosage adjustment is necessary in patients with moderate to severe renal impairment, hepatic impairment and patients on dialysis.
Dry mouth, constipation, transient bradycardia (followed by tachycardia , arrhythmias), dilatation of the pupils, raised intraocular pressure have been reported infrequently during treatment with Hyoscine- N-Butyl Bromide.
Caution should be exercised when driving a car or o perating heavy machineries. Concurrent use of Cetirizine with alcohol or other CNS depressants sh ould be avoided because reduction in alertness and impairment of CNS activity may occur. Children: Cetirizine is effective and well-tolerated in chil dren. No special precautions are required in children over 6 years of age.
Use In Pregnancy Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women using Cet irizine. Therefore Cetirizine should be used in pregnancy only if clearly needed. Lactating Mother: Cetirizine has been reported to be excreted in breast milk and thus, use of Cetirizine in lactatin g mother is not recommended.
Cetirizine is contraindicated in patients who have shown hypersensitivity or idiosyncrasy to it or its parent compound- Hydroxyzine.
Store in a cool and dry place
Nosemin Tablet: Box contains 100 (10x10's) tablets in blister strip. Nosemin Syrup: Amber glass bottle contains 60 ml syrup.