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Terbulin tablet 2.5 mg: Each tablet contains Terbutaline sulfate BP 2.5 mg. Terbulin Syrup: Each 5 ml syrup contains Terbutaline sulfate BP 1.5 mg.

Terbulin (Terbutaline) is indicated for the symptomatic treatment of reversible bronchospasm associated with asthma, chronic bronchitis, emphysema and related bronchospastic disorders.

Tablet: Adult: 5 mg 3 times daily. If excessive side effects occur, dose may be reduced to 2.5 mg 3 times daily. Children 12 to 15 years: 2.5 mg 3 times daily. Children 6 to 11 years: dose should be according to body weight i.e. 0.075 mg/kg body weight 3 times daily. Syrup Adults: 10-15 ml, 2-3 times a day Children: 0.075mg (0.25 ml)/kg. body weight), 3 times in a 24 hour period. The following serves as a guideline. Children 7-15 years: 5-10ml 2-3 times a day (1-2 teaspoonful). Children 3-6 years: 2.5-5 ml 2-4 times a day (1/2-1 teaspoonful). 2 years: 2.5 ml 2-3 times a day (1/2 teaspoonful)

The following side effects are observed- Gastrointestinal: Nausea, vomiting, epigastric pain, diarrhoea, anorexia, reactivation of peptic ulcer. CNS: Headache, irritation, restlessness, insomnia, muscle twitching. Cardiovascular: Palpitation, tachycardia, hypotension, circulatory failure. Respiratory: Tachypnoea. Renal: Albuminuria, diuresis and hematuria. Others: Hyperglycemia and inappropriate ADH syndrome.

Caution should be exercised when Terbutaline is used concurrently with sympathomimetic amines, since the incidence and severity of adverse reactions may be increased. The concurrent administration of other Xanthine derivatives along with Terbutaline sustained release tablets is not recommended. Terbutaline should also be used with caution in elderly patients, and patients with severe hypoxemia, uncompensated cardiac failure, or those with history of peptic ulcer.

Terbutaline crosses the placental barrier and also passes freely into breast milk, where concentrations are similar to plasma levels. Safe use in pregnancy and adverse effects on fetal development have not been established. Therefore caution must be used in prescribing Terbutaline to pregnant woman or nursing mother , taking into account the risk-benefit of this therapy.

Cimetidine, erythromycin, influenza vaccine, allopurinol, ciprofloxacin, lithium carbonate, oral contraceptives and propranolol increases the serum level by decreasing the renal clearance and a reduced dose may therefore be needed to avoid the side effects. On the other hand the renal clearance is increased by barbiturates, phenytoin, rifampcin and smoking. Concurrent use of several xanthines or concurrent use of sympathomimetics with Terbutaline may cause excessive CNS stimulation.

Should not be administered to patients with hypersensitivity to Terbutaline or other Xanthine derivatives, peptic ulcer, coronary artery diseases.

Terbulin tablet 2.5 mg: Each box contains 10x 10's tablets in blister strip. Terbulin syrup: Each bottle contains 100 ml syrup.