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Sinatrim
Co-trimoxazole
| NAME | STRENGTH | PACK SIZE | DOSAGE FORM |
|---|---|---|---|
| Sinatrim | 400 mg + 80 mg | 10X10 | Tablet |
| Sinatrim-DS | 800 mg + 160 mg | 10X10 | Tablet |
| Sinatrim 60 | 200 mg + 40 mg / 5 ml | 60 ml | Suspension |
Description
Sinatrim (Co-trimoxazole) having broad spectrum bactericidal activity against a wide range of gram-positive & gram-negative bacteria and some protozoa. Co-trimoxazole containing Trimethoprim BP and Sulphamethoxazole BP in a 1:5 combination exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid in the microorganism.
Composition
Sinatrim Tablet: Each tablet contains Trimethoprim BP 80 mg and Sulphamethoxazole BP 400 mg. Sinatrim DS Tablet: Each tablet contains Trimethoprim BP 160 mg and Sulphamethoxazole BP 800 mg. Sinatrim Suspension: Each 5 ml contains Trimethoprim BP 40 mg and Sulphamethoxazole BP 200 mg.
Indications And Uses
Sinatrim is indicated in all bacterial infections caused by susceptible organisms. These include -Respiratory tract infection: Acute and chronic bronchitis, bronchiectasis, lung abscess, lobar & broncho-pneumonia, pneumocystis carinii pneumonitis, sinusitis and otitis media. Genito-urinary tract infection: Urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, gonorrhoea. Gastro-intestinal tract infection: Typhoid, cholera and shigellosis. Skin infection: Pyoderma, abscess and wound infection. Other infections: Acute and chronic osteomyelitis, acute brucellosis, septicemia, nocardiosis and actinomycetoma.
Dosage And Administration
Adult and children over 12 years usual dose: One Sinatrim DS tablet twice daily for at least 5 days or until the patient has been symptom free. For prostatitis and acute brucellosis, it should be maintained for at least 4 weeks and require long term therapy for actinomycetoma. In severe infection and septicemia: Three Sinatrim tablets twice daily. Gonorrhoea: Two Sinatrim DS tablet twice daily over 2 days or, three Sinatrim tablets 8 hourly. Dosage for long-term treatment (>14 days): One Sinatrim tablet twice daily. Prophylaxis of recurrent urinary tract infection: One Sinatrim tablet at night. Pneumocystis carinii infection: 120 mg/kg body weight in divided doses up to 14 days. Children: 6 weeks to 5 months: Sinatrim suspension 1/2 teaspoonful twice daily. 6 months to 5 years: Sinatrim suspension 1 teaspoonful twice daily. 6 years to 12 years: Sinatrim suspension 2 teaspoonful or Sinatrim tablet twice daily.
Side Effect
Crystalluria, allergic reaction, haemolysis, thrombocytopenia, neutropenia, agranulocytosis, malaise, headache, purpura, nausea, vomiting, skin rash, erythema multiforme etc.
Precaution
To avoid crystalluria, plenty of water should intake during treatment with co-trimoxazole. The drug is to be taken with caution during breast feeding. In prolonged treatment complete blood count is to be performed at monthly intervals.
Contraindications
Co-trimoxazole is contraindicated in patients who have shown hypersensitivity to its ingredients, patients with megaloblastic anaemia, liver damage, blood dyscrasia, severe renal insufficiency. This drug should not be given in pregnancy and infant under 6 week.
How Supplied
Sinatrim Tablet: Box contains 10 x 10's tablet in blister strip. Sinatrim DS Tablet: Box contains 10x10's tablet in blister strip. Sinatrim Suspension: Bottle contains 60 ml suspension.