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Racecadotril BP

Rehydril 100 mg 100 mg 3X10 Capsule


Rehydril (Racecadotril) is a prodrug that needs to be hydrolysed to its active metabolite thiorphan. Thiorphan is an inhibitor of enkephalinase. Enkephalinase is a cell membrane peptidase located in various tissues, notably in the epithelium of the small intestine. This enzyme hydrolyses or breaks down the exogenous peptides and endogenous peptides (enkephalins). Racecadotril protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing water and electrolytes hypersecretion. Racecadotril exerts rapid antidiarrhoeal action, without modifying the duration of intestinal transit. Racecadotril does not produce abdominal distension.

Each capsule contains Racecadotril BP 100 mg.

Rehydril (Racecadotril) is indicated as an adjunct to rehydration therapy for the symptomatic treatment of acute secretory diarrhoea.

One capsule initially regardless of the time of day; then one capsule 3 times daily (preferably before food) until diarrhoea stops. Treatment should not exceed 7 days.

Headache, rash and erythema.

The administration of Racecadotril does not modify the usual rehydration regimens. There are limited data in patients with renal or hepatic impairment. So these patients should be treated with caution.

Due to a lack of clinical data, Racecadotril should not be administered to pregnant or breastfeeding women.

No interactions with other active substances have been described in humans to date. In humans, joint treatment with Racecadotril and Loperamide, or Nifuroxazide does not modify the kinetics of Racecadotril.

Keep in a dry place away from light and heat. Keep out of the reach of children.

Racecadotril is contraindicated in patients who have shown hypersensitivity to its components.

Each box contains 3x10 capsules in Alu-Alu blister pack.