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Nepafenac is a nonsteroidal anti-inflammatory prodrug (NSAID). After instillation in the eye, it penetrates the cornea and is converted by ocular tissue hydrolase to Amfenac, a potent nonsteroidal anti-inflammatory drug. Amfenac is thought to inhibit the action of cyclooxygenase enzyme. This enzyme is required for prostaglandin synthesis.
Each ml sterile ophthalmic suspension contains Nepafenac INN 3 mg.
Indications And Uses
Post-operative pain and inflammation associated with cataract surgery.
Dosage And Administration
For post-operative pain & inflammation: Instill 1 drop once daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period. An additional drop should be administered 30 to 120 minutes prior to surgery.
Reported side effects are foreign body sensation, lid margin crusting, ocular discomfort, ocular hyperemia etc.
Nepafenac should be used with caution in patients with known bleeding tendencies or who are receiving medications which may prolong bleeding time.
Use In Pregnancy Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Nepafenac should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: It is not known whether this drug is excreted in human milk. So, caution should be exercised when Nepafenac ophthalmic suspension is administered to a nursing mother.
No information available.
No information provided.
Store in a cool and dry place away from light. Keep out of reach of children.
Contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients in the formulation or to other NSAIDs.
Each plastic dropper bottle contains 5 ml sterile ophthalmic suspension.