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FLOROMOX-D
Moxifloxacin BP + Dexamethasone Phosphate USP
| NAME | STRENGTH | PACK SIZE | DOSAGE FORM |
|---|---|---|---|
| Floromox-D | 0.5% w/v + 0.1% w/v | 5 ml | Eye drops |
Description
The mechanism of action of Moxifloxacin involves the inhibition of topoisomerase IV and DNA gyrase, Dexamethasone inhibits phospholipase A2 enzyme and thus inhibits prostaglandin synthesis and gives anti-inflammatory action.
Composition
Each ml contains Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 5 mg & Dexamethasone Sodium Phosphate USP equivalent to Dexamethasone Phosphate 1 mg.
Indications And Uses
It is indicated in the treatment of eye infections caused by susceptible microorganisms and in the prevention of inflammation and bacterial infection that may occur after eye surgery.
Dosage And Administration
In the prevention of infection and post-surgical ocular inflammation: Instill 1 drop, 4 times a day, in the eye to be operated, from 1 day before surgery until 15 days after surgery. In patients undergoing cataract surgery: The day of surgery instill the medication immediately after eye surgery. In patients undergoing LASIK refractive surgery: On the day of surgery instill the medication at least 15 minutes after ocular surgery. In eye infections caused by susceptible microorganisms: Instill 1 drop, 4 times a day, for up to 7 days.
Side Effect
Moxifloxacin: Conjunctivitis decreased visual acuity, dry eye, keratitis, Ocular discomfort, hyperemia, pain, Subconjunctival hemorrhage and tearing. Dexamethasone: Visual acuity & field defects, cataract formation, secondary ocular infection following suppression of host response & perforation of the globe.
Precaution
For ophthalmic use only Solution should not be injected under the conjunctiva, nor introduced directly into the anterior chamber of the eyeProlonged use of steroids may result in ocular hypertension
Use In Pregnancy Lactation
There are no adequate and well-controlled studies in pregnant women. Moxifloxacin & Dexamethasone combination eye drops should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use in lactation: Caution is advised when Moxifloxacin & Dexamethasone combination eye drops is given to nursing women.
Drug Interactions
Moxifloxacin: Drug-drug interaction studies have not been conducted with moxifloxacin. Dexamethasone: The risk of increased intraocular pressure associated with prolonged corticosteroid therapy.
Overdosage
No information available.
Storage
Store below 30° C at cool and dry place, protect from light. Keep out of reach of children.
Contraindications
Hypersensitivity to quinolones. Epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella & other viral diseases of cornea & conjunctiva. Mycobacterial infection of the eye. Fungal diseases of ocular structures. Glaucoma & diseases causing thinning of cornea or sclera.
How Supplied
FLOROMOX-D Eye Drops: Each plastic dropper bottle contains 5 ml sterile & pyrogen free eye drops.