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Cloram (Chloramphenicol) Eye/Ear Drops is 0.5% ophthalmic and otic antiinfective sterile solution of Chloramphenicol. Cloram Eye ointment is 1 % ophthalmic anti-infective sterile ointment of Chloramphenicol.Chloramphenicol is a potent, broad spectrum antibiotic and is effective against a wide range of gram-positive and gram-negative organisms. The drug is bacteriostatic and interferes with protein synthesis. It penetrates cornea, conjunctiva and into the aqueous humor of eye and excreted by the nasolacrimai system. Chloramphenicol also inhibits or destroys the bacteria present in ear canal. The drug begins to act within one hour.
Cloram Eye/Ear Drops: Each ml contains Chloramphenicol BP 5 mg. Cloram eye Ointment: Each gm contains Chloramphenicol BP 10 mg.
Indications And Uses
Eye drop: Because of its wide range of antibacterial spectrum Cloram Eye Drops and Eye Ointment are used in a variety of infections caused by sensitive organisms such as: conjunctivitis, blepharitis, corneal ulcer, dacryocystitis etc. Ear drop: Cloram ear drops is indicated in external ear canal infection.
Dosage And Administration
Eye drop: 2 drops of solution in eye every 3 hours or more frequently if required. Ear drop: 2 to 3 drops into ear canal three or four times daily. Administration should be continued for 48 hours after symptoms have been disappeared. Eye ointment: One application of ointment to lower conjunctival sac every 3 hours or more frequently if required.
Systemic adverse reaction has not been reported with short term topical use of Chloramphenicol. Rarely, optic atrophy in children, stinging and burning of the eye in patient sensitive to Chloramphenicol may be experienced.
Chloramphenicol should never be given for minor infections or for prophylaxis. Repeated courses and prolonged treatment should be avoided. If discharge is profused, the ear canal should be carefully cleaned and a quarter inch gauze impregnated with the ear-drops should be introduced.
Chloramphenicol is contraindicated in patients with a history of hypersensitivity or toxic reaction to it.
Cloram Eye/Ear Drops: Dropper bottle contains 10 ml sterile drops. Cloram eye ointment: Tube contains 5 gm sterile ointment.