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Clindamycin as Clindamycin Hydrochloride BP
|300 mg/2 ml
|600 mg/4 ml
Clindamycin is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms.Clindamycin is a semisynthetic antibiotic derived from lincomycin.
Cinamycin 150 Capsule: Each capsule contains Clindamycin Hydrochloride BP equivalent to Clindamycin 150 mg. Cinamycin 300 Capsule: Each capsule contains Clindamycin Hydrochloride BP equivalent to Clindamycin 300 mg. Cinamycin 300 IV/IM injection: Each 2ml ampoule contains Clindamycin Phosphate USP equivalent to Clindamycin 300 mg. Cinamycin 600 IV/IM injection: Each 4ml ampoule contains Clindamycin Phosphate USP equivalent to Clindamycin 600 mg.
Indications And Uses
Clindamycin HCl is indicated in the treatment of the following infections caused by susceptible anaerobic bacteria or susceptible strains of gram positive bacteria such as Streptococci, Staphylococci and Pneumococci; Upper respiratory infections, Lower respiratory infections, Skin and soft tissue infections, Bone and joint infections, Pelvic infections, Intra-abdominal infections, Septicemia and endocarditis, Dental infections. As an alternative therapy when used in combination with quinine or amodiaquine for the treatment of multi-drug resistant Plasmodium falciporum infection.
Dosage And Administration
Capsule: Serious infections- 150 to 300 mg every 6 hours. More severe infections- 300 to 450 mg every 6 hours. To avoid the possibility of oesophageal irritation, Cinamycin capsules should be taken with a full glass of water. IV/IM injection: 0.6-2.7g daily (in 2-4 divided doses): life threatening infection, upto 4.8g daily. Single doses by intravenous not to exceed 1.2g. Child: Over one month, 15-40mg/kg daily in 3-4 divided doses, severe infections, at least 300 mg daily regardless of weight.
The adverse effects have been reported with the use of clindamycin are- abdominal pain, oesophagitis and oesophagial ulcer, nausea, vomiting and diarrhoea, pruritus, skin rashes, urticaria
Cinamycin should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Use In Pregnancy Lactation
Pregnancy Category B. Clindamycin has been reported to appear in breast milk in the range of 0.7 to 3.8 mcg/mL. So this drug should be used only if clearly needed.
Clindamycin enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents. Antagonism has been demonstrated between clindamycin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
Overdosage with orally administered clindamycin has been rare. Adverse reactions similar to those seen with normal doses can be expected, however, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Overdosage should be treated with simple gastric lavage. No specific antidote is known.
Clindamycin is contraindicated in patients previously found to be sensitive to clindamycin or any of the ingredients of this medicine.
Cinamycin 150 Capsule: Each box contains 30 Capsule in Alu-Alu blister. Cinamycin 300 Capsule: Each box contains 30 Capsule in Alu-Alu blister. Cinamycin 300 IV/IM injection: Each box contains 5 ampoules of 2ml solution in Alu-PVC blister. Cinamycin 600 IV/IM injection: Each box contains 5 ampoules of 4ml solution in Alu-PVC blister.