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Diltiazem HCl USP
Cardil (Diltiazem) is a calcium-channel blocker with peripheral and coronary vasodilator properties. It lowers blood pressure and has some effect on cardiac conduction. Cardil interferes with the influx of calcium ions through the channels of active cell membranes.
Cardil -30: Each tablet contains Diltiazem HCl USP 30 mg. Cardil -60: Each tablet contains Diltiazem HCl USP 60 mg.
Indications And Uses
Cardil is used for the prophylaxis and treatment of chronic stable (classical) and vasopastic angina pectoris and has also been used alone or in combination in the management of hypertension, also, Cardil is effective in myocardial infarction, coronary artery spasm, arrhythmias, Raynaud's phenomenon, oesophageal motility disorder and migraine.
Dosage And Administration
Adult: The usual dose is 60 mg thrice daily. However patient's response may vary and dosage requirements can differ significantly between individual patients. If necessary, the divided dose may be increased to 180- 300mg/day. Dosage may be started as 30 mg four times daily and increasing at 1 to 2 days intervals until the optimum response is achieved. Higher doses upto 480mg/day have been used with benefit in some patients especially in unstable angina. Elderly and patients with impaired hepatic or renal function : The recommended starting dose is 60 mg twice daily. The heart rate should be measurecfregularly and the dose should not be increased if the heart rate falls bejew 50 beats per minute. Children: Not recommended.
With Diltiazem headache, ankle oedema, hypertension, dizziness, flushing, rashes (toxic erythema), nausea and Gl disturbances may occur. Transient elevation in liver enzyme values and occasionally hepatitis have been reported. Diltiazem may depress cardiac conduction and has occasionally led to AV block, bradycardia and rarely asystole or sinus arrest.
Cardil should be used with care in patients with lesser degrees of AV block or bradycardia; also in patients with impaired left ventricular function. Caution should be required in patients with impaired liver or kidney function.
Use In Pregnancy Lactation
There are no adequate and controlled studies to date with diltiazem in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risk to the fetus. Because diltiazem is distributed into milk, women receiving the drug should not breastfeed their infants; an alternative method of infant feeding should be used if diltiazem therapy is considered necessary in nursing women.
Digoxin, Propranolol, Cyclosporin, Theophylline, Cimetidine, Lithium & Carbamazepine.
Keep medicine out of the reach of children. Store in a cool and dry place.
Cardil is contraindicated to the patients of severe bradycardia, sick sinus syndrome, pregnancy, second or third degree AV block.
Cardil -30: Each box contains 10x10 's film coated Diltiazem 30 mg tablet in blister strip. Cardil -60: Each box contains 10x10 's film coated Diltiazem 60 mg tablet in blister strip.