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Brimonidin Tartrate + Timolol Maleate

Bimolet 0.2% w/v + 0.5% w/v 5 ml Eye drops


Brimonidine is more selective for the alpha-2 adrenoreceptor. It is thought that Brimonidine Tartrate lowers IOP by enhancing uveoscleral outflow and reducing aqueous humor formation. Timolol is a beta 1 and beta 2 non-selective adrenergic receptor blocking agent. Timolol lowers IOP by reducing aqueous humor formation. The precise mechanism of action is not clearly established, predominant action may be related to reduce aqueous formation. However, in some studies a slight increase in outflow facility was also observed.

Bimolet Sterile Eye Drops: Each ml contains Brimonidine Tartrate INN 2 mg and Timolol Maleate BP equivalent to Timolol 5 mg.

Bimolet is indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP.

The recommended dose is one drop of this eye drops in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, other eye drops should be instilled at least 5 minutes apart. Safety and effectiveness in children below the age of 2 years have not been established.

The most frequent reactions of this combination are allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, blepharitis, corneal erosion, epiphora, eye dryness, eye pain, eyelid edema, eyelid pruritus, headache, hypertension, superficial punctate keratitis, and visual disturbance.

Like other topically applied ophthalmic agents, it may be absorbed systemically. Due to the presence of Timolol, the same types of cardiovascular and pulmonary adverse reactions as seen with systemic beta-blockers may occur. Cautions should be exercised in treating patients with severe or unstable and uncontrolled cardiovascular or pulmonary diseases.

Pregnancy: Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Bimolet should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Timolol has been detected in human milk but it is not known whether Brimonidine Tartrate is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Specific drug interaction studies on this ophthalmic preparation have not been established.

No information is available on overdoses with this drop in humans.

Store in a cool & dry place, protected from light. Keep out of reach of children. Do not use more than 30 days after first opening.

Contraindicated in patients with hypersensitivity to any component of this product. Also contraindicated in bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure and cardiogenic shock.

Bimolet Sterile Eye Drops: Each plastic dropper bottle contains 5 ml sterile eye drops.